Publications
Most PDFs are freely available from once the embargo period is over, and many DOI links below connect to open-access publications. The symbol * indicates present/former students or postdoctoral fellows in the 鶹ý Coastal Hydrology lab when part/all of the work was completed.
2024
*Smith KA, Kurylyk BL. 2024. Pumping groundwater to create cold-water thermal refuges in warming rivers, Ecohydrology, e2739, DOI: .
*Xun Y, Xu X, Kurylyk B, Li X, Mu D, Huang G. 2024. Mechanistic simulation of salt-affected soil-plant-atmosphere continuum dynamics in seasonally frozen regions, Water Resources Research, 60(11),e2024WR037815, DOI:.
*Craddock R, *Mohammed AM, Tamborski J, Kurylyk BL. 2024. Submarine groundwater discharge at a mega-tidal beach, Hydrological Processes, 38(11), e15319, DOI: .
*Cantelon JA, Kurylyk BL. 2024. Storm surge, seawater flooding, and sea-level rise paradoxically drive fresh surface water expansion, Environmental Research Letters, 19, 124038, DOI:.
Irvine DJ, Singha K, Kurylyk BL, Briggs MA, Sebastian Y, Tait DR, Helton AM. 2024. Groundwater surface water interactions research: Past trends and future directions, Journal of Hydrology, 644, 132061, DOI: .
*Oliver AC, Kurylyk BL, Johnston LH, *LeRoux NK, Somers LD, Jamieson RC. 2024. Impacts of climate change and best management practices on nitrate loading to a eutrophic coastal lagoon, Frontiers in Environmental Science, 12, 1468869, DOI: .
*Smith KA, McKenzie JM, Kurylyk BL. 2024. Tidal pumping and intertidal groundwater springs create pronounced spatiotemporal thermal variability in a coastal lagoon, Limnology and Oceanography, 69(10), 2263-2277. DOI: .
Lin Y-F, Rau G, Kurylyk BL. 2024. Application of the image-well method for transient borehole thermal energy storage systems with complex boundaries, Heat Transfer, DOI: .
Normandeau A, Eamer J, Way R, Harrison E, Cyr F, Algar C, Eamer J, Geizer H, Kurylyk BL, Van Nieuwenhove N, Pijogge L, Robert K, Saunders M, Limoges A, Tamborski J. 2024. Evidence for subsea permafrost in subarctic Canada linked to submarine groundwater discharge,Nature Geoscience,17, 1022–1030. DOI: .
*Benz SA, Irvine DJ, Rau G, Bayer P, Menberg K, Bayer P, Blum P, Jamieson RC, Griebler C, Kurylyk BL. 2024. Global groundwater warming due to climate change,Nature Geoscience,17, 545–551. DOI: .
*Tackley HA, Kurylyk BL, Lake CB. 2024. Impacts of groundwater dynamics around a macrotidal river on agricultural soil salinity, Science of the Total Environment, 927, 172344. DOI: .
Kurylyk BL, Lin Y-F, Solórzano-Rivas C, Werner AD. 2024. Analytical methodology for determining the extent of pumped freshwater lenses in recharge-limited, circular islands, Advances in Water Resources, 187, 104693. DOI: .
*Oliver AC, Jamieson RC, *Smith KA, *Cantelon JC, Kurylyk BL. 2024. Intertidal spring dynamics and coastal nutrient loading revealed through geophysics, drone surveys, and in-situ monitoring, Hydrological Processes, 38(5), e15144. DOI:
*Cantelon JA, *LeRoux NK, Mulligan RP, Swatridge LL, Kurylyk BL. 2024. Interrelated coastal flooding, erosion, and groundwater salinization on a barrier island during Hurricane Fiona, Journal of Geophysical Research - Earth Surface, 129(4), e2023JF007551. DOI:
*Guimond JA, Kurylyk BL, Sohn R. 2024. Seasonal drivers and patterns of soil temperatures in a New England salt marsh, Hydrological Processes, 38(2), e15100. DOI:
Mahdavi A, Kurylyk BL, Lin Y-F. 2024. Advanced analytical model for oscillatory pumping tests with wellbore skin and rate-dependent skin effects, Water Resources Research, 60(2), e2023WR035291. DOI:
*LeRoux NK, *Pavlovskii I, O’Sullivan AM, Mulligan RP, *Bonnington AC, Kurylyk BL. 2024. Morphodynamics of a mixed sand-cobble beach in response to extratropical cyclone Fiona and seasonal wave variability, Science of the Total Environment, 916, 170077. DOI:
*Stanic S, *LeRoux NK, Paldor A, *Mohammed AA, Michael HA, Kurylyk BL. 2024.Saltwater intrusion into a confined island aquifer driven by erosion, changing recharge, sea-level rise, and coastal flooding,Water Resources Research, 60(1), e2023WR036394, DOI:
Wade J, Kelleher C, Kurylyk BL. 2024. Incorporating physically-based water temperature predictions into the National Water Model Framework,Environmental Modelling and Software, 171, 105866, DOI:
2023
*LeRoux NK, Frey S, Lapen DR, Guimond JA, Kurylyk BL. 2023. Mega-tidal and surface flooding controls on coastal groundwater and saltwater intrusion within agricultural dikelands, Water Resources Research, 59(11), e2023WR035054, DOI:
*Bonnington A, Jamieson RC, *Smith KA, *Oliver A, Johnston LH, *LeRoux NK, Somers LD, Kurylyk BL. 2023. Extratropical cyclone impacts on a sensitive coastal ecosystem, Limnology and Oceanography, 68(12), 2703-2715, DOI:
*Cantelon JC, Robinson C, Kurylyk BL. 2023. Morphologic, atmospheric, and oceanic drivers of multi-temporal saltwater intrusion on a remote, sand island,Water Resources Research, 59(10),e2023WR035820, DOI:
*Smith KA, O’Sullivan A, Kennedy GK, *Benz S, Somers LD, Kurylyk BL. 2023. Shallow groundwater temperature patterns revealed through a regional monitoring well network, Hydrological Processes, 37(9), e14975, DOI:
*Guimond JA, Demur C, Kurylyk BL, Walvoord MA, McClelland J, Cardenas MB. 2023. Wind-modulated groundwater discharge along a microtidal Arctic coastline, Environmental Research Letters, 18, 094042, DOI: .
Mulligan RP, Swatridge R, *Cantelon JA, Kurylyk BL, George E, Houser C. 2023.Local and remote storm surge contributions to total water levels in the Gulf of St. Lawrence during Hurricane Fiona,Journal of Geophysical Research - Oceans, 128(8),e2023JC019910, DOI:
*Tackley HA, Kurylyk BL, Lake C, Lapen D, van Proosdij D. 2023. Impacts of repeated coastal flooding on soil and groundwater following managed dike realignment, Science of the Total Environment, 893, 164957, DOI: .
Mejia F, Ouellet, V, Briggs MA, Carlson S, Casas-Mulet R, Chapman M, Collins, M, Dugdale S, Ebersole J, Frechette D, Fullerton A, Gillis C-A, Johnson Z, Kelleher C, Kurylyk BL, Lave R, Letcher B, Myrvold K, Nadeau T-L, Neville H, Piégay H, *Smith KA, Tonolla D, Torgersen CE. 2023. Closing the gap between science and management of cold-water refuges in rivers and streams, Global Change Biology, 29(19), 5482-5508, DOI: .
Kurylyk BL, *Smith KA. Stuck in the middle: Thermal regimes of coastal lagoons and estuaries in a warming world, Environmental Research Letters, 18(6), 061003, DOI:
*Pavlovskii I, Jiang Y, Danielescu S, Kurylyk BL. 2023. Influence of precipitation event magnitude on baseflow and coastal nitrate export for Prince Edward Island, Canada, Hydrological Processes, 37(5), e14892, DOI:
Hare D, *Benz S, Kurylyk BL, Johnson ZC, Terry N, Helton A. 2023. Paired air and stream temperature analysis (PASTA) to evaluate groundwater influence on streams, Water Resources Research, 59, 4, e2022WR033912, DOI:
Bermarjia T, Johnston LH, Green CS, Kurylyk BL, Jamieson RC. 2023. Assessing and predicting lake chloride concentrations in a lake-rich urbanizing region, Journal of Hydrology: Regional Studies, 47, 01377, DOI:
Leach JA, Kelleher C, Kurylyk BL, Moore RD, Nielson BT. 2023. A primer on stream temperature processes, WIREs Water, e1643, DOI:
2022
O’Sullivan A, Kurylyk BL. 2022. Limiting external absorptivity of UAV-based uncooled thermal infrared sensors increases water temperature measurement accuracy, Remote Sensing, 14(24), 6356, DOI:
*Mohammed AM, *Guimond JA, Bense VF, Jamieson RC, McKenzie JM, Kurylyk BL. Mobilization of subsurface carbon pools driven by permafrost thaw and reactivation of groundwater flow: A virtual experiment, Environmental Research Letters, 17, 124036, DOI:
*Threndyle R, Jamieson RC, Kennedy G, Lake CB, Kurylyk BL. 2022. Future inundation of coastal on-site wastewater treatment systems in a region with pronounced sea-level rise, Journal of Hydrology, 614, 128548, DOI:
*Cantelon JA, *Guimond JA, Robinson C, Michael HA, Kurylyk BL. 2022. Vertical saltwater intrusion in coastal aquifers driven by episodic flooding: A review, Water Resources Research,58, e2022WR032614, DOI: .
*Craddock RD, Kennedy GW, Jamieson RC, Keizer J, *Mohammed AA, Kurylyk BL. 2022. Assessment of groundwater discharge pathways in a till-dominated coastal aquifer.Journal of Hydrology: Regional Studies, 44, 101205.DOI: .
*KarisAllen JJ, *Mohammed AM, *Tamborski JJ, Jamieson RC, Danielescu S, Kurylyk BL. 2022. Present and future thermal regimes of intertial groundwater springs in a threatened coastal ecosystem.Hydrology and Earth System Sciences, 26(18), 4721-4740, DOI: .
Feng Z, Duan L, Kurylyk BL, Cai T. 2022.Impacts of permafrost thaw on streamflow recession in a discontinuous permafrost watershed of northeastern China.Science of the Total Environment, 847(157624). DOI: .
*Benz SA, Menberg K, Bayer P, Kurylyk BL. 2022. Shallow subsurface heat recycling is a sustainable global space heating alternative. Nature Communications, 13, 3962.DOI:.
Johnston LH, Dunnington DW, Greenwood M, Kurylyk BL, Jamieson RC. Identifying hydrologic regimes and drivers in Nova Scotia, Canada: catchment classification efforts for a data-limited region, ASCE Journal of Hydrologic Engineering, 27(11), 05022017. DOI: .
*Pavlovskii I, *Cantelon JA, Kurylyk BL. 2022. Coastal groundwater model calibration using filtered and amplified hydraulic information retained in the freshwater-saltwater interface, Hydrogeology Journal,30, 1551–1567, DOI: .
O'Sullivan AM, Linnansaari T, Leavitt J, Samways KM, Kurylyk BL, Curry RA. 2022. The salmon-peloton: Hydraulic habitat shifts of adult Atlantic Salmon (Salmo salar) due to behavioural thermoregulation, River Research and Applications,38(1), 107-118, DOI:.
*Guimond JA, *Mohammed AM, Walvoord MA, Bense VF, Kurylyk BL. 2022. Sea-level rise and warming mediate coastal groundwater discharge in the Arctic, Environmental Research Letters, 17(4), 045027, DOI:
*Threndyle R, Kurylyk BL, Huang Y, Johnston LH, Jamieson RC. 2022. CrAssphage is a sensitive indicator of groundwater-borne pollution in coastal ecosystems, Environmental Research Communications, 4(5), 051001, DOI:
Bense VF, Kruijssen T, van der Ploeg MP, Kurylyk BL. 2022. Inferring aquitard properties using transient temperature-depth profiles impacted by ground surface warming, Water Resources Research, 58(5),e2021WR030586, DOI:
*Monfared YE, Kurylyk BL, Dasog M. 2022. Highly sensitive plasmonic fiber-optic sensors using Group IV transition metal nitrides: a numerical investigation.Plasmonics, 17, 931-940, DOI:.
2021
*Guimond JA, *Mohammed AM, Walvoord MA, Bense VF, Kurylyk BL. 2021. Saltwater intrusion intensifies coastal permafrost thaw. Geophysical Research Letters, 48(19),e2021GL094776, DOI:.
*Mohammed AM, Bense VF, Kurylyk BL, Jamieson RC, Johnston LH, Jackson AJ. 2021. Modeling reactive solute transport in permafrost-affected groundwater systems. Water Resources Research, 57(7), e2020WR028771, DOI: .
Sherren K, Ellis K, *Guimond JA, Kurylyk BL, *Leroux NK, Lundholm J, Mallory ML, van Proosdij D, Walker AK, Bowron TM, Brazner J, Kellman L, Turner BL, Wells E. 2021. Understanding multifunctional Bay of Fundy dykelands and tidal wetlands using ecosystem services – a baseline, FACETS, 6, 1446-1473, DOI: .
Sullivan CJ, Vokoun JC, Helton AM, Briggs MA, Kurylyk BL. 2021. An ecohydrological typology for thermal refuges in streams and rivers, Ecohydrology, 14(5), e2295, DOI: .
*KarisAllen J, Kurylyk BL. 2021. Drone-based characterization of intertidal spring cold-water plume dynamics,Hydrological Processes(HPEye), 35(6),e14258, DOI:.
*LeRoux NK, Kurylyk BL, Briggs MA, Irvine DJ, *Tamborski JJ, Bense VF. 2021. Using heat to trace vertical water fluxes in sediment experiencing concurrent tidal pumping and groundwater discharge. Water Resources Research, 57(2), e2020WR027904, DOI:.
*Tamborski JJ, Gonneea M, Kurylyk BL, Kroeger K, Wang Z, Henderson P, Charette M. 2021. Porewater exchange driven inorganic carbon export from intertidal salt marshes, Limnology and Oceanography, 66(5): 1774-792, DOI: .
Bennet EM, Baird J, Baulch H, Chaplin-Kramer R, Fraser E, Loring P, Morrison M, Parrott L, Sherren K, Winkler KJ, Cimon-Morin J, Fortin M-J, Kurylyk BL, Lundholm J, Poulin M, Rieb JT, Gonzalez A, Hickey GM, Humphries M, Krishna KC, Lapen D. 2021. Ecosystem services and the resilience of agricultural landscapes.Advances in Ecological Research, 64, 1-43, DOI:.
Briggs MA, Cantelon JA, Kurylyk BL, Kulongoski JT, MIlls A, Lane JW. 2021.Small atoll fresh groundwater lenses respond to a combination of natural climatic cycles and human modified geology.Science of the Total Environment, 756, 143838.DOI:.
McKenzie JM, Kurylyk BL, Walvoord MA, Bense VF, Fortier D, Spence S, Grenier G. 2021. Invited perspective: What lies beneath a changing Arctic.The Cryosphere, 15, 479-484. DOI:.
2020
Kurylyk BL and Walvoord MA. 2020. Permafrost hydrogeology. Invited chapter (pp. 493-523) in (D Yang and D Kane, eds.), Springer Press.
Lamontagne-Hallé P, McKenzie JM, Kurylyk BL, Molson J, Lyon LN. 2020. Guidelines for cold-regions groundwater numerical modeling. WIREs Water,e1467.DOI:.
Fabris L, Rolick RL, Kurylyk BL, Carey SK. 2020. Characterization of contrasting flow and thermal regimes in two adjacent subarctic alpine headwaters in northwest Canada. Hydrological Processes, 34(15): 3252-3270.DOI:.
Bense VF,Kurylyk BL,de Bruin JGH, Visser P. 2020.Repeated subsurface thermal profiling to reveal temporal variability in deep groundwater flow conditions.Water Resources Research,56, e2019WR026913.DOI:.
Wu R, Martin V, McKenzie JM, Broda S, Bussière B, Aubertin M, Kurylyk BL. 2020. Laboratory scale assessment of a capillary barrier using Fibre Optic Distributed Temperature Sensing (FO-DTS).Canadian Geotechnical Journal, 57(1): 115-126.DOI:.
Irvine DJ,Kurylyk BL, Briggs MA. 2020. Quantitative guidance for efficient vertical flow measurements at the sediment-water interface using temperature-depth profiles.Hydrological Processes, 34(3): 649-661.DOI: .
2019
Kurylyk BL. 2019. Engineering challenges of warming (Editors invited News and Views). Nature Climate Change, 9, 807–808.DOI:.
Kurylyk BL, Irvine DI. 2019. Heat: An overlooked tool in the practicing hydrogeologist's toolbox.Groundwater, 57(4).DOI:.
Kurylyk BL, Irvine DJ, Bense VF. 2019. Theory, tools, and multidisciplinary applications for tracing groundwater fluxes from temperature profiles. WIREs Water, 6: e1239.DOI:.
2018
Mohammed AA, Kurylyk BL, Cey E, Hayashi M. 2018. Snowmelt infiltration and macropore flow in frozen soils: overview, knowledge gaps and a conceptual framework.Vadose Zone Journal, 17(1).DOI:.
Lamontagne-Hallé P, McKenzie JM, Kurylyk BL, Zipper SC. 2018. Changing groundwater discharge dynamics in permafrost regions, Environmental Research Letters, 13(8).DOI:.
Kurylyk BL, Irvine DJ, Mohammed AA, Bense VF, Briggs MA, Loder JW, Geshelin Y. 2018 Rethinking the use of seabed sediment temperature profiles to trace submarine groundwater flow, Water Resources Research, 54: 4595-4614.DOI:.
Briggs MA, Johnson ZC, Snyder CD, Hitt NP, Kurylyk BL, Lautz L, Irvine DJ, Hurley ST, Lane JW. 2018. Inferring watershed hydraulics and cold-water habitat persistence using multi-year air and stream temperature signals, Science of the Total Environment, 636: 1117-1127.DOI:.
Grenier C, Anbergen H, Bense V, Chanzy Q, Coon E, Collier N, Costard F, Ferry M, Frampton A, Frederick J, Goncalves J, Holmen J, Jost A, Kokh S, Kurylyk BL, McKenzie J, Molson J, Mouche E, Orgogozo L, Pannetier R, Riviere A, Roux N, Rühaak W, Scheidegger J, Selroos J-O, Therrien R, Vidstrand P, Voss C. 2018. Groundwater flow and heat transport for systems undergoing freeze-thaw: Intercomparison of numerical simulators for 2D test cases, Advances in Water Resources, 114: 196-218.DOI:.
Amiri E, Craig JR, Kurylyk BL. 2018. A theoretical extension of the soil freezing curve paradigm, Advances in Water Resources, 111: 319-328.DOI:.
2017
Bense VF, Kurylyk BL. 2017. Tracking the subsurface signal of decadal climate warming to quantify vertical groundwater flow, Geophysical Research Letters, 44: 12,244-12,253.DOI:.
Harrington JS, Hayashi M, Kurylyk BL. 2017. Influence of a rock glacier spring on the stream energy budget and cold-water refuge in an alpine stream. Hydrological Processes, 31: 4719-4733.DOI:.
Bense VF, Kurylyk BL, van Daal J, van der Ploeg MJ, Carey SK. 2017. Interpreting repeated temperature-depth profiles for groundwater flow, Water Resources Research, 53: 8639-8647.DOI:.
Kurylyk BL, Hayashi M. 2017. Inferring hydraulic properties of alpine aquifers from the propagation of diurnal snowmelt signals. Water Resources Research, 53: 4271-4285.DOI:.
Kurylyk BL, Irvine DJ, Carey SK, Briggs MA, Werkema DD, Bonham M. 2017. Heat as a groundwater tracer in shallow and deep heterogeneous media: analytical solution, spreadsheet tool, and field applications. Hydrological Processes, 31; 2648-2661.DOI:.
Duan L, Man X, Li Q, Kurylyk BL, Yu Z. 2017. Distinguishing streamflow trends caused by changes in climate, forest cover, and permafrost in a large watershed in northeastern China. Hydrological Processes, 31: 1938-1951.DOI:.
Duan L, Man X, Kurylyk BL, Cai T. 2017. Increasing winter baseflow in response to permafrost thaw and precipitation regime shifts in northeastern China. Water, 9(1).DOI:.
Irvine DJ, Kurylyk BL, Cartwright I, Bonham, M. Post VEA, Banks EW, Simmons CT. 2017. Groundwater flow estimation using temperature-depth profiles in a complex environment and a changing climate. Science of the Total Environment, 574: 272-281.DOI:.
Morton S, MacQuarrie KTB, Connor D, Kurylyk BL. 2017. Monitoring changes in near-well hydraulic conditions as a means to assess aquifer clogging. Journal of Hydrologic Engineering (ASCE), 22(2).DOI:.
2016
Kurylyk BL, Hayashi M, Quinton WL, McKenzie JM, Voss CI. 2016. Influence of vertical and lateral heat transfer on permafrost thaw, peatland landscape transition, and groundwater flow. Water Resources Research, 52: 1286-1305.DOI:.
Walvoord MA, Kurylyk BL. 2016. Hydrologic impacts of permafrost thaw – A review. Vadose Zone Journal, 15 (6).DOI:.
Kurylyk BL, Irvine DI. 2016. Analytical solution and computer program (FAST) to estimate fluid fluxes from subsurface temperature-depth profiles. Water Resources Research, 52: 725-733.DOI:.
Kurylyk BL, Moore RD, MacQuarrie KTB. 2016. Scientific briefing: Quantifying streambed heat advection associated with groundwater-surface water interactions, Hydrological Processes, 30: 987-92.DOI:.
Kurylyk BL, Hayashi M. 2016. Improved Stefan equation correction factors to accommodate soil sensible heat storage during freezing or thawing. Permafrost and Periglacial Processes, 27:189-203.DOI:.
2015
Kurylyk BL, MacQuarrie KTB, Linnansaari T, Cunjak RA, Curry RA. 2015. Preserving, augmenting and creating cold-water thermal refugia in rivers: Concepts derived from the Miramichi River, New Brunswick (Canada). Ecohydrology, 8: 1095-1108.DOI:.
Rühaak W, Anbergen H, Grenier C, McKenzie JM, Kurylyk BL, Molson J, Roux N, Sass I. 2015. Benchmarking numerical freeze/thaw models. Energy Procedia, 76: 301-310.DOI:.
Kurylyk BL, MacQuarrie KTB, Caissie D, McKenzie JM. 2015. Shallow groundwater thermal sensitivity to climate change and land cover disturbances: Derivation of analytical expressions and implications for stream temperature modeling. Hydrology and Earth Systems Sciences, 19: 2469-2489.DOI:.
Kurylyk BL. 2015. Discussion of: “A simple thaw-freeze algorithm for a multi-layered soil using the Stefan equation” by Xie and Gough, 2013. Permafrost and Periglacial Processes, 26: 200-206.DOI:.
2014
Caissie D, Kurylyk BL, St-Hilaire A, El-Jabi N, MacQuarrie KTB. 2014. Streambed temperature dynamics and corresponding heat fluxes in small streams experiencing seasonal ice cover. Journal of Hydrology, 519: 1441-1452. DOI:.
Menberg K, Blum P, Kurylyk BL, Bayer P. 2014. Observed groundwater temperature response to recent climate change. Hydrology and Earth Systems Sciences, 18: 4453-4466.DOI:
Kurylyk BL, MacQuarrie KTB, McKenzie JM. 2014. Climate change impacts on groundwater and soil temperatures in cold and temperate regions: Implications, mathematical theory, and emerging simulation tools. Earth-Science Reviews, 138: 313-334.DOI:.
Kurylyk BL, McKenzie JM, MacQuarrie KTB, Voss CI. 2014. Analytical solutions for benchmarking cold regions subsurface water flow and energy transport models: one-dimensional soil thaw with conduction and advection. Advances in Water Resources, 70: 172-184.DOI:.
Kurylyk BL, MacQuarrie KTB, Voss CI. 2014. Climate change impacts on the temperature and magnitude of groundwater discharge from shallow, unconfined aquifers. Water Resources Research, 50: 3253-3274.DOI:.
Kurylyk BL, MacQuarrie KTB. 2014. A new analytical solution for assessing projected climate change impacts on subsurface temperature. Hydrological Processes, 28: 3161-3172.DOI:.
2013
Kurylyk BL, MacQuarrie KTB. 2013. The uncertainty associated with estimating future groundwater recharge: A summary of recent research and an example from a small unconfined aquifer in a northern climate. Journal of Hydrology, 492: 244-253.DOI:.
Kurylyk BL, Watanabe K. 2013. The mathematical representation of freezing and thawing processes in variably-saturated, non-deformable soils. Advances in Water Resources, 60:160-177. DOI:.
Kurylyk BL, Bourque CPA, MacQuarrie KTB. 2013. Potential surface temperature and shallow groundwater temperature response to climate change: an example from a small forested catchment in east-central New Brunswick (Canada). Hydrology and Earth System Sciences, 17: 2701-2716. DOI:.